New PDF release: Absorption and Drug Development: Solubility, Permeability,

By Alex Avdeef

ISBN-10: 1118057457

ISBN-13: 9781118057452

Explains the way to practice and examine the result of the most recent physicochemical methods

With this booklet as their advisor, readers have entry to the entire present details had to completely examine and correctly make certain a compound's pharmaceutical homes and their results on drug absorption. The ebook emphasizes oral absorption, explaining the entire physicochemical equipment used this present day to research drug applicants. in addition, the writer offers specialist advice to assist readers study the result of their experiences that allows you to opt for the main promising drug candidates.

This Second Edition has been completely up to date and revised, incorporating all of the most up-to-date study findings, tools, and assets, including:

  • Descriptions and functions of recent PAMPA versions, drawing on greater than thirty papers released by way of the author's examine group

  • Two new chapters analyzing permeability and Caco-2/MDCK and permeability and the blood-brain barrier

  • Expanded details and strategies to aid pKa determination

  • New examples explaining the therapy of essentially insoluble try compounds

  • Additional case experiences demonstrating using the newest physicochemical techniques

  • New, revised, and extended database tables in the course of the book

Well over two hundred drawings support readers greater comprehend tricky suggestions and supply a visible consultant to complicated methods. additionally, over 800 references function a gateway to the first literature within the box, facilitating extra examine into the entire issues coated within the book.

This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of analysis. it's also instructed as a supplemental textual content for graduate classes in pharmaceutics.

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Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef


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